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Keep track of Carefully (one)pentobarbital will lessen the level or effect of fentanyl intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to your lessen in fentanyl plasma concentrations, deficiency of efficacy or, quite possibly, pro